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According to the results obtained, Daphnia magna is probably the most delicate organism, and resorcinol may be categorised as acutely poisonous solely to Daphnia. However, pvp modena is questionable to be used as a restrict worth in risk assessment this is the very best focus tested on this examine , and the NOEC could be significantly larger than said within the research. In the ambiance, resorcinol is quickly degraded half-life about 2 h by response with photochemically produced hydroxyl radicals. Under cardio situations, resorcinol proved to be readily biodegradable in a test carried out based on OECD TG C, and it's likely to be biodegraded beneath anaerobic circumstances.


Hence, an improved biodegradation fee results in lowered risks for the environment. Regarding the consequences of resorcinol on aquatic species, the toxicity information set contains a variety of species from totally different trophic levels. Results from exams with different aquatic species from totally different trophic ranges can be found for the acute toxicity of resorcinol to aquatic organisms.


From the scarce data available, the usage of resorcinol in hair dyes zero. The use of anti-pimples cream is taken because the scenario of most concern as a result of likelihood of continuous exposure.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and treated skin areas showed slight erythema and extreme dryness. Mean information for three donors and 16 replicates point out a plateau in receptor fluid focus between 24 and forty eight h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.







  • In animal research, the toxicological effects reported to be caused by administration of resorcinol embrace thyroid dysfunction, irritation to skin and eyes, CNS effects, and altered adrenal gland relative weights.




  • In one research carried out with male Syrian golden hamsters, which focused only on results on the forestomach, pyloric region, and urinary bladder, the animals had been dosed with 0 or zero.




  • From these data, the authors concluded that male rats have a higher capacity for glucuronidation than females.




  • The organisms had been exposed to the test concentrations for 96 h.




  • According to the results obtained, Daphnia magna is essentially the most delicate organism, and resorcinol could be categorised as acutely toxic solely to Daphnia.




  • Van Leeuwen et al.




  • Thyroid glands from all surviving F zero mother and father have been examined microscopically, and mind measurements were carried out on all uncovered F 1 pups and those F 1 pups chosen for behavioural testing.





British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are no epidemiological knowledge relevant to the carcinogenicity of resorcinol in people and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol is not classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the usage of resorcinol as a food flavouring agent and concluded that this use is of no safety concern. Overall, the research are not sufficient for a statistical extrapolation technique in accordance with the EU Technical Guidance Document EC, a.


The elimination was biphasic, with half-lives of 18—21 min and eight. The 14 C exercise was quickly distributed in major tissues corresponding to muscle tissue, kidneys, and liver, without indication of bioaccumulation Merker et al. pvp modena being provided in the midst of the OECD evaluation might be provided to the IPCS so that an addendum could be ready for consideration.
In , medical examinations see above and thyroid assessments had been performed with of presumably energetic plant staff men and 33 girls. Flaked resorcinol caused no perceptible to reasonable irritation intact pores and skin or no perceptible necrosis abraded skin.
Other skin results had been hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there were no systemic treatment-related lesions. With resorcinol, a number of initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group were treated with two subcutaneous injections of. In a research carried out by Hasegawa et al.
Fifty per cent of survivors have been sacrificed 1 week later, and blood and urine samples were taken. Resorcinol showed a focus-dependent increase in labelling index [ three H]thymidine , acanthosis, and papillomatosis. After utility of an ointment containing To research the goitrogenic exercise of resorcinol, feminine Wistar rats were handled twice every day for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.


Furthermore, persistent research with fish and Daphnia had been carried out. For the toxicity to aquatic crops, no guideline examine is available. However, taking into account the available studies for toxicity to aquatic crops, the NOEC for algae could be assumed to be greater than that for Daphnia magna. Exposure to resorcinol by means of peeling agents presents an acute publicity situation the place the particular person is uncovered to a high focus 7. Acute effects have been described beneath these circumstances.