Different studies performed with rats and mice gave no increase within the micronucleus formation in bone marrow cells. Bone marrow smears have been ready at 30 h, and polychromatic erythrocytes per animal have been scored Gocke et al. An interim sacrifice at 15 months gave no difference in haematology, scientific chemistry, or other medical pathology parameters and no elevated incidence of neoplasms or non-neoplastic lesions. Also, at final sacrifice, there was no evidence of carcinogenic exercise in males or females of both species.
Apart from one constructive single case-examine Vilaplana et al. In these cases, the examined concentration of resorcinol was 0. The data are summarized in Table 8. Data concerning the totally different job classes weren't provided.
Determination of resorcinol conjugates in the h urine samples after 14 days of continuous product therapy showed that a maximal 23 mg 2. Assuming a body weight of sixty four kg IPCS, gives an publicity estimate of zero. In a report based mostly on consumer research data Gans, , under reasonable maximum-use conditions i.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there aren't any epidemiological information relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the studies aren't adequate for a statistical extrapolation approach based on the EU Technical Guidance Document EC, a.
The organisms were exposed to the take a look at concentrations for 96 h. Biological observations were performed day by day.
In apply, nevertheless, the incidence of sensitization seems to be low. In animal research, the toxicological effects reported to be attributable to administration of resorcinol include thyroid dysfunction, irritation to pores and skin and eyes, CNS results, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, such as dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or pink blood cell modifications, such as methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One issue growing potential toxic effects is the application of resorcinol to injured pores and skin.
In in vitro genotoxicity checks, resorcinol confirmed mostly unfavorable results. Results from all reported in vivo exams for genotoxicity have been adverse. Mostly negative results had been reported in the initiation—promotion research performed using several species. UV irradiation caused no increased skin reactions. The iodination process is catalysed by a haem-containing enzyme.
In one other examine, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the research of Yeung et al.
The results had been more pronounced at 72 h. The irritation index was given as four. However, owing to missing correlating histopathological modifications in the three levels of the brain examined and within the absence of a dose—response relationship, different indicators of developmental delay, or different changes in CNS operate, these effects were not thought-about as conclusive proof of a change in CNS perform. In the subsequent two-technology reproductive toxicity study RTF, , these finish-factors were not investigated. No resorcinol-associated effects on F zero and F 1 pup survival or the final bodily situation of the pups during the pre-weaning period have been noticed.
There are variations in thyroid physiology between people and animals. The weight of proof suggests that rodents are more sensitive to thyroid effects than people.