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<br /><br />For the benthic and terrestrial compartments, the obtainable toxicity information cannot be considered sufficient for a quantitative risk characterization. However, these compartments are less relevant for resorcinol, due to marginal releases and emissions to these compartments in addition to a very low potential for adsorption of resorcinol to natural matter.<br />There are variations in thyroid physiology between humans and animals. The weight of evidence suggests that rodents are extra sensitive to thyroid effects than humans.<br /><br />No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic goal organ results had been observed within the F zero and F 1 parental animals. The F 0 and F 1 females continued to obtain the resorcinol all through mating, gestation, and lactation and thru the day of euthanasia for study design, see Appendix 7. There have been no F zero and F 1 parental resorcinol-related deaths or medical findings through the weekly detailed physical examinations. In controls and the excessive-dose group, a qualitative histopathological analysis of the mind forebrain, midbrain, and hindbrain was additionally performed for the aforementioned animals RTF, There were no adverse results regarding reproductive performance, mortality, and body or organ weights.<br />These figures agree properly with the above publicity estimate primarily based on the Yeung et al.<br />Animals that died confirmed hyperaemia and distension of abdomen and gut, whereas there were no gross lesions at necropsy in survivors Flickinger, In another examine with CFY rats. Most of the research are of sufficient quality and acceptable for danger characterization purposes.<br /><br /><h1></h1><br /><br /><ul><br />  <br />  <br />  <br /> <li>In controls and the excessive-dose group, a qualitative histopathological analysis of the brain forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There had been no antagonistic effects concerning reproductive efficiency, mortality, and body or organ weights.</li><br /> <br /> <br /> <br /> <li>In one study performed with male Syrian golden hamsters, which centered only on effects on the forestomach, pyloric region, and urinary bladder, the animals had been dosed with zero or 0.</li><br />  <br />  <br />  <br /> <li>Biological observations had been carried out every day.</li><br />  <br />  <br />  <br /> <li>Hence, an improved biodegradation price leads to lowered risks for the setting.</li><br /> <br /> <br /> <br /></ul><br />Other pores and skin effects have been hyperplasia, hyperkeratosis, inflammation, and sebaceous gland hyperplasia, whereas there were no systemic therapy-related lesions. With resorcinol, several initiation—promotion research with hamsters Maruyama et al. Female Syrian golden hamsters 10—20 per group were treated with two subcutaneous injections of. In a study performed by Hasegawa et al.<br />The organisms had been uncovered to the check concentrations for 96 h. Biological observations have been carried out every day.<br />There isn't any guideline examine on toxicity for aquatic vegetation out there. As just one concentration was examined, the examine can't be used within the risk analysis. There are a number of studies obtainable on acute toxicity to completely different fish species.<br />More traditional-use circumstances would end in exposures of about 0. Further particulars were not given.<br />In follow, nevertheless, the incidence of sensitization appears to be low. In animal studies, the toxicological effects reported to be brought on by administration of resorcinol embody thyroid dysfunction, irritation to skin and eyes, CNS effects, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, corresponding to dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or pink blood cell changes, similar to methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One factor rising potential poisonous effects is the appliance of resorcinol to injured skin.<br /><br /><h4></h4><br />The microscopic examination of the thyroid gave minimal modifications follicular hyperplasia , which had been statistically not significant between controls and individual dose groups RTF, In vitro research have been performed to evaluate the consequences of resorcinol on thyroid function. In high-dose groups, a lower in body weight and decreased survival were noted. Owing to concern in regards to the thyroid results of resorcinol, which have been shown in human studies to happen at excessive doses, this end-point particularly has been the purpose of focus in several research. In many of the older studies, the results of resorcinol publicity on the thyroid gland are conflicting. It has been suggested that thyroid effects seem to be dependent on an administration route that permits for continued systemic publicity e.<br /><br /><h2></h2><br />In in vitro genotoxicity exams, resorcinol confirmed principally unfavorable results. Results from all reported in vivo exams for genotoxicity had been unfavorable. Mostly adverse results have been reported within the initiation—promotion studies carried out using several species. UV irradiation brought on no increased skin reactions. The iodination course of is catalysed by a haem-containing enzyme.
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<br /><br />Different studies performed with rats and mice gave no increase within the micronucleus formation in bone marrow cells. Bone marrow smears have been ready at 30 h, and polychromatic erythrocytes per animal have been scored Gocke et al. An interim sacrifice at 15 months gave no difference in haematology, scientific chemistry, or other medical pathology parameters and no elevated incidence of neoplasms or non-neoplastic lesions. Also, at final sacrifice, there was no evidence of carcinogenic exercise in males or females of both species.<br />Apart from one constructive single case-examine Vilaplana et al. In these cases, the examined concentration of resorcinol was 0. The data are summarized in Table 8. Data concerning the totally different job classes weren't provided.<br /><br /><h1></h1><br />Determination of resorcinol conjugates in the h urine samples after 14 days of continuous product therapy showed that a maximal 23 mg 2. Assuming a body weight of sixty four kg IPCS, gives an publicity estimate of zero. In a report based mostly on consumer research data Gans, , under reasonable maximum-use conditions i.<br /><br /><h2></h2><br />British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there aren't any epidemiological information relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the studies aren't adequate for a statistical extrapolation approach based on the EU Technical Guidance Document EC, a.<br /><br /><h4></h4><br />The organisms were exposed to the take a look at concentrations for 96 h. Biological observations were performed day by day.<br />In apply, nevertheless, the incidence of sensitization seems to be low. In animal research, the toxicological effects reported to be attributable to administration of resorcinol include thyroid dysfunction, irritation to pores and skin and eyes, CNS results, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, such as dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or pink blood cell modifications, such as methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One issue growing potential toxic effects is the application of resorcinol to injured pores and skin.<br />In in vitro genotoxicity checks, resorcinol confirmed mostly unfavorable results. Results from all reported in vivo exams for genotoxicity have been adverse. Mostly negative results had been reported in the initiation—promotion research performed using several species. UV irradiation caused no increased skin reactions. The iodination process is catalysed by a haem-containing enzyme.<br />In one other examine, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the research of Yeung et al.<br /><br />The results had been more pronounced at 72 h. The irritation index was given as four. However, owing to missing correlating histopathological modifications in the three levels of the brain examined and within the absence of a dose—response relationship, different indicators of developmental delay, or different changes in CNS operate, these effects were not thought-about as conclusive proof of a change in CNS perform. In the subsequent two-technology reproductive toxicity study RTF, , these finish-factors were not investigated. No resorcinol-associated effects on F zero and F 1 pup survival or the final bodily situation of the pups during the pre-weaning period have been noticed.<br />There are variations in thyroid physiology between people and animals. The weight of proof suggests that rodents are more sensitive to thyroid effects than people.

Revision as of 19:03, 28 March 2020



Different studies performed with rats and mice gave no increase within the micronucleus formation in bone marrow cells. Bone marrow smears have been ready at 30 h, and polychromatic erythrocytes per animal have been scored Gocke et al. An interim sacrifice at 15 months gave no difference in haematology, scientific chemistry, or other medical pathology parameters and no elevated incidence of neoplasms or non-neoplastic lesions. Also, at final sacrifice, there was no evidence of carcinogenic exercise in males or females of both species.
Apart from one constructive single case-examine Vilaplana et al. In these cases, the examined concentration of resorcinol was 0. The data are summarized in Table 8. Data concerning the totally different job classes weren't provided.


Determination of resorcinol conjugates in the h urine samples after 14 days of continuous product therapy showed that a maximal 23 mg 2. Assuming a body weight of sixty four kg IPCS, gives an publicity estimate of zero. In a report based mostly on consumer research data Gans, , under reasonable maximum-use conditions i.


British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there aren't any epidemiological information relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol isn't classifiable as to its carcinogenicity to people. JECFA assessed the hazards from the use of resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the studies aren't adequate for a statistical extrapolation approach based on the EU Technical Guidance Document EC, a.


The organisms were exposed to the take a look at concentrations for 96 h. Biological observations were performed day by day.
In apply, nevertheless, the incidence of sensitization seems to be low. In animal research, the toxicological effects reported to be attributable to administration of resorcinol include thyroid dysfunction, irritation to pores and skin and eyes, CNS results, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, such as dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or pink blood cell modifications, such as methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One issue growing potential toxic effects is the application of resorcinol to injured pores and skin.
In in vitro genotoxicity checks, resorcinol confirmed mostly unfavorable results. Results from all reported in vivo exams for genotoxicity have been adverse. Mostly negative results had been reported in the initiation—promotion research performed using several species. UV irradiation caused no increased skin reactions. The iodination process is catalysed by a haem-containing enzyme.
In one other examine, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the research of Yeung et al.

The results had been more pronounced at 72 h. The irritation index was given as four. However, owing to missing correlating histopathological modifications in the three levels of the brain examined and within the absence of a dose—response relationship, different indicators of developmental delay, or different changes in CNS operate, these effects were not thought-about as conclusive proof of a change in CNS perform. In the subsequent two-technology reproductive toxicity study RTF, , these finish-factors were not investigated. No resorcinol-associated effects on F zero and F 1 pup survival or the final bodily situation of the pups during the pre-weaning period have been noticed.
There are variations in thyroid physiology between people and animals. The weight of proof suggests that rodents are more sensitive to thyroid effects than people.